CD34 and p53 Immunohistochemical Stains Differentiate Hypocellular Myelodysplastic Syndrome (hMDS) from Aplastic Anemia and a CD34 Immunohistochemical Stain Provides Useful Survival Information for hMDS
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CD34 and p53 Immunohistochemical Stains Differentiate Hypocellular Myelodysplastic Syndrome (hMDS) from Aplastic Anemia and a CD34 Immunohistochemical Stain Provides Useful Survival Information for hMDS
BACKGROUND The presence of significant dysplasia in bone marrow (BM) aspirates helps to distinguish between hypocellular myelodysplastic syndrome (hMDS) and aplastic anemia (AA). Occasionally, diluted BM aspirates make it difficult to recognize dysplastic changes and can also negatively affect the detection of cytogenetic abnormalities in hMDS. We evaluated the usefulness of CD34 and p53 immuno...
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Members of the French-American-British Cooperative Leukemia Working Group met to review cases of aplastic anemia, hypocellular myelodysplastic syndrome and hypocellular acute myeloid leukemia. Criteria were proposed and modified following three workshops. Additional input was obtained from another hematopathologist with a special interest in bone marrow histology and immunohistochemistry. Guide...
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Dear Editor, Refractory cytopenia of childhood (RCC) is the most common subtype of hypoplastic myelodysplastic syndrome (hMDS) in childhood, characterized by persistent cytopenia, dysplastic changes in erythroid precursors or megakaryocytes, and the presence of erythroid islands, defined as more than 10 erythroid precursors in a bone marrow (BM) biopsy section [1, 2]. Since 75% of the patients ...
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In aplastic anemia (AA), contraction of the stem cell pool may result in oligoclonality, while in myelodysplastic syndromes (MDS) a single hematopoietic clone often characterized by chromosomal aberrations expands and outcompetes normal stem cells. We analyzed patients with AA (N 93) and hypocellular MDS (hMDS, N 24) using single nucleotide polymorphism arrays (SNP-A) complementing routine cyto...
متن کاملSNP array-based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes.
In aplastic anemia (AA), contraction of the stem cell pool may result in oligoclonality, while in myelodysplastic syndromes (MDS) a single hematopoietic clone often characterized by chromosomal aberrations expands and outcompetes normal stem cells. We analyzed patients with AA (N = 93) and hypocellular MDS (hMDS, N = 24) using single nucleotide polymorphism arrays (SNP-A) complementing routine ...
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ژورنال
عنوان ژورنال: Annals of Laboratory Medicine
سال: 2014
ISSN: 2234-3806,2234-3814
DOI: 10.3343/alm.2014.34.6.426